HORDB

ID: hor000944
Uniprot ID: Q9TS44
Protein name: Cholecystokinin-58
Gene name: CCK
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Family: Gastrin/cholecystokinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Canis lupus (species), Canis (genus), Canidae (family), Caniformia (suborder), Carnivora (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
GO BP: GO:0007165 signal transduction; GO:0007586 digestion; GO:0032094 response to food
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030424 axon

Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.stimulate amylase release from the pancreas.increases bile-pancreatic volume
Mechanism: NA
Cross BBB: NA
Target: CCKAR
Target Unid: Q5D0K2
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q9TS44-F1.pdb

hor000944_AF2.pdb

hor000944_ESM.pdb

Mass:	762648	Formula:	C288H462N90O83S3
Absent amino acids:	CT	Common amino acids:	ARDL
pI:	10.31	Basic residues:	11
Polar residues:	12	Hydrophobic residues:	19
Hydrophobicity:	-61.72	Boman Index:	-13676
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	79.14
Instability Index:	3846.72	Extinction Coefficient cystines:	8480
Absorbance 280nm:	148.77

PubMed ID: 2430967
Title: New Molecular Forms of Cholecystokinin. Microsequence Analysis of Forms Previously Characterized by Chromatographic Methods.
PubMed ID: 7134033
Title: Partial Structure of a Large Canine Cholecystokinin (CCK58): Amino Acid Sequence.
PubMed ID: 12686463
Title: Synthesis of Biologically Active Canine CCK-58.
PubMed ID: 15064233
Title: Identification of Nonsulfated cholecystokinin-58 in Canine Intestinal Extracts and Its Biological Properties
PubMed ID: 6093106
Title: Isolation of a Large Cholecystokinin Precursor From Canine Brain.
PubMed ID: 1713209
Title: Characterization of Canine Intestinal cholecystokinin-58 Lacking Its Carboxyl-Terminal Nonapeptide. Evidence for Similar Post-Translational Processing in Brain and Gut